PDB 4zbi

PDB Information

PDB4ZBI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W.
J.Med.Chem.
HeaderApoptosis/Apoptosis Inhibitor
Released2015-04-14
Resolution2.500
CATH Insert Date28 Jun, 2015

PDB Images (25)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped
I 29 Jun, 2015 Chopped
J 29 Jun, 2015 Chopped
K 29 Jun, 2015 Chopped
L 29 Jun, 2015 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
4zbiA01 27 Jul, 2015 1.10.437.10 Assigned
4zbiB01 27 Jul, 2015 1.10.437.10 Assigned
4zbiC01 27 Jul, 2015 1.10.437.10 Assigned
4zbiD01 27 Jul, 2015 1.10.437.10 Assigned
4zbiE01 27 Jul, 2015 1.10.437.10 Assigned
4zbiF01 27 Jul, 2015 1.10.437.10 Assigned
4zbiG01 27 Jul, 2015 1.10.437.10 Assigned
4zbiH01 27 Jul, 2015 1.10.437.10 Assigned
4zbiI01 27 Jul, 2015 1.10.437.10 Assigned
4zbiJ01 27 Jul, 2015 1.10.437.10 Assigned
4zbiK01 27 Jul, 2015 1.10.437.10 Assigned
4zbiL01 27 Jul, 2015 1.10.437.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1