PDB 4zbf

PDB Links
Overview

PDB Information

PDB	4ZBF
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W. J.Med.Chem.
Header	Apoptosis/Apoptosis Inhibitor
Released	2015-04-14
Resolution	2.200
CATH Insert Date	28 Jun, 2015

PDB Images (25)

4zbf

PDB 4zbf

4zbfA

PDB Chain 4zbfA

4zbfB

PDB Chain 4zbfB

4zbfC

PDB Chain 4zbfC

4zbfD

PDB Chain 4zbfD

4zbfE

PDB Chain 4zbfE

4zbfF

PDB Chain 4zbfF

4zbfG

PDB Chain 4zbfG

4zbfH

PDB Chain 4zbfH

4zbfI

PDB Chain 4zbfI

4zbfJ

PDB Chain 4zbfJ

4zbfK

PDB Chain 4zbfK

4zbfL

PDB Chain 4zbfL

4zbfA01

CATH Domain 4zbfA01

4zbfB01

CATH Domain 4zbfB01

4zbfC01

CATH Domain 4zbfC01

4zbfD01

CATH Domain 4zbfD01

4zbfE01

CATH Domain 4zbfE01

4zbfF01

CATH Domain 4zbfF01

4zbfG01

CATH Domain 4zbfG01

4zbfH01

CATH Domain 4zbfH01

4zbfI01

CATH Domain 4zbfI01

4zbfJ01

CATH Domain 4zbfJ01

4zbfK01

CATH Domain 4zbfK01

4zbfL01

CATH Domain 4zbfL01

PDB Prints

PDB Chains (12)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped
C	29 Jun, 2015	Chopped
D	29 Jun, 2015	Chopped
E	29 Jun, 2015	Chopped
F	29 Jun, 2015	Chopped
G	29 Jun, 2015	Chopped
H	29 Jun, 2015	Chopped
I	29 Jun, 2015	Chopped
J	29 Jun, 2015	Chopped
K	29 Jun, 2015	Chopped
L	29 Jun, 2015	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4zbfA01	27 Jul, 2015	1.10.437.10	Assigned
4zbfB01	27 Jul, 2015	1.10.437.10	Assigned
4zbfC01	27 Jul, 2015	1.10.437.10	Assigned
4zbfD01	27 Jul, 2015	1.10.437.10	Assigned
4zbfE01	27 Jul, 2015	1.10.437.10	Assigned
4zbfF01	27 Jul, 2015	1.10.437.10	Assigned
4zbfG01	27 Jul, 2015	1.10.437.10	Assigned
4zbfH01	27 Jul, 2015	1.10.437.10	Assigned
4zbfI01	27 Jul, 2015	1.10.437.10	Assigned
4zbfJ01	27 Jul, 2015	1.10.437.10	Assigned
4zbfK01	27 Jul, 2015	1.10.437.10	Assigned
4zbfL01	27 Jul, 2015	1.10.437.10	Assigned

UniProtKB Entries (12)

Accession	Gene ID	Taxon	Description
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1