PDB 4ykn

PDB Links
Overview

PDB Information

PDB	4YKN
Method	X-RAY DIFFRACTION
Host Organism	unidentified baculovirus
Gene Source	Homo sapiens
Primary Citation	Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT). Yang, H., Medeiros, P.F., Raha, K., Elkins, P., Lind, K.E., Lehr, R., Adams, N.D., Burgess, J.L., Schmidt, S.J., Knight, S.D., Auger, K.R., Schaber, M.D., Franklin, G.J., Ding, Y., DeLorey, J.L., Centrella, P.A., Mataruse, S., Skinner, S.R., Clark, M.A., Cuozzo, J.W., Evindar, G. Acs Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2015-03-04
Resolution	2.900
CATH Insert Date	28 Jun, 2015

PDB Images (10)

Image of CATH 4ykn

4ykn

PDB 4ykn

Image of CATH 4yknA

4yknA

PDB Chain 4yknA

Image of CATH 4yknA01

4yknA01

CATH Domain 4yknA01

Image of CATH 4yknA02

4yknA02

CATH Domain 4yknA02

Image of CATH 4yknA03

4yknA03

CATH Domain 4yknA03

Image of CATH 4yknA04

4yknA04

CATH Domain 4yknA04

Image of CATH 4yknA05

4yknA05

CATH Domain 4yknA05

Image of CATH 4yknA06

4yknA06

CATH Domain 4yknA06

Image of CATH 4yknA07

4yknA07

CATH Domain 4yknA07

Image of CATH 4yknA08

4yknA08

CATH Domain 4yknA08

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4yknA01	12 Jul, 2018		Holding pen
4yknA02	12 Jul, 2018	1.10.287.1490	Assigned
4yknA03	12 Jul, 2018	3.10.20.90	Assigned
4yknA04	12 Jul, 2018	3.10.20.90	Assigned
4yknA05	12 Jul, 2018	2.60.40.150	Assigned
4yknA06	12 Jul, 2018	1.25.40.70	Assigned
4yknA07	12 Jul, 2018	3.30.1010.10	Assigned
4yknA08	12 Jul, 2018	1.10.1070.11	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P27986	P85A_HUMAN	Homo sapiens	Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336	PK3CA_HUMAN	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform