PDB 4ykn

PDB Information

PDB4YKN
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Yang, H., Medeiros, P.F., Raha, K., Elkins, P., Lind, K.E., Lehr, R., Adams, N.D., Burgess, J.L., Schmidt, S.J., Knight, S.D., Auger, K.R., Schaber, M.D., Franklin, G.J., Ding, Y., DeLorey, J.L., Centrella, P.A., Mataruse, S., Skinner, S.R., Clark, M.A., Cuozzo, J.W., Evindar, G.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-03-04
Resolution2.900
CATH Insert Date28 Jun, 2015

PDB Images (10)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4yknA01 12 Jul, 2018 Holding pen
4yknA02 12 Jul, 2018 1.10.287.1490 Assigned
4yknA03 12 Jul, 2018 3.10.20.90 Assigned
4yknA04 12 Jul, 2018 3.10.20.90 Assigned
4yknA05 12 Jul, 2018 2.60.40.150 Assigned
4yknA06 12 Jul, 2018 1.25.40.70 Assigned
4yknA07 12 Jul, 2018 3.30.1010.10 Assigned
4yknA08 12 Jul, 2018 1.10.1070.11 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P27986 P85A_HUMAN Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336 PK3CA_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform