PDB 4xs2

PDB Information

PDB4XS2
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHomo sapiens
Primary Citation
Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4.
McElroy, W.T., Michael Seganish, W., Jason Herr, R., Harding, J., Yang, J., Yet, L., Komanduri, V., Prakash, K.C., Lavey, B., Tulshian, D., Greenlee, W.J., Sondey, C., Fischmann, T.O., Niu, X.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-01-21
Resolution2.730
CATH Insert Date28 Jun, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4xs2A01 22 Jul, 2015 3.30.200.20 Assigned
4xs2A02 22 Jul, 2015 1.10.510.10 Assigned
4xs2B01 22 Jul, 2015 3.30.200.20 Assigned
4xs2B02 22 Jul, 2015 1.10.510.10 Assigned
4xs2C01 22 Jul, 2015 3.30.200.20 Assigned
4xs2C02 22 Jul, 2015 1.10.510.10 Assigned
4xs2D01 20 Jul, 2015 3.30.200.20 Assigned
4xs2D02 20 Jul, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4