PDB 4xry

PDB Information

PDB4XRY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors.
Brodney, M.A., Beck, E.M., Butler, C.R., Barreiro, G., Johnson, E.F., Riddell, D., Parris, K., Nolan, C.E., Fan, Y., Atchison, K., Gonzales, C., Robshaw, A.E., Doran, S.D., Bundesmann, M.W., Buzon, L., Dutra, J., Henegar, K., LaChapelle, E., Hou, X., Rogers, B.N., Pandit, J., Lira, R., Martinez-Alsina, L., Mikochik, P., Murray, J.C., Ogilvie, K., Price, L., Sakya, S.M., Yu, A., Zhang, Y., O'Neill, B.T.
J.Med.Chem.
HeaderOxidoreductase
Released2015-01-21
Resolution2.500
CATH Insert Date28 Jun, 2015

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4xryA00 22 Jul, 2015 1.10.630.10 Assigned
4xryB00 22 Jul, 2015 1.10.630.10 Assigned
4xryC00 22 Jul, 2015 1.10.630.10 Assigned
4xryD00 22 Jul, 2015 1.10.630.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6