PDB 4wz8

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Overview

PDB Information

PDB	4WZ8
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Saccharomyces cerevisiae
Primary Citation	Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. Griffith, D.A., Kung, D.W., Esler, W.P., Amor, P.A., Bagley, S.W., Beysen, C., Carvajal-Gonzalez, S., Doran, S.D., Limberakis, C., Mathiowetz, A.M., McPherson, K., Price, D.A., Ravussin, E., Sonnenberg, G.E., Southers, J.A., Sweet, L.J., Turner, S.M., Vajdos, F.F. J.Med.Chem.
Header	Ligase/Ligase Inhibitor
Released	2014-11-18
Resolution	2.230
CATH Insert Date	21 Dec, 2014

PDB Images (9)

Image of CATH 4wz8

4wz8

PDB 4wz8

Image of CATH 4wz8B

4wz8B

PDB Chain 4wz8B

Image of CATH 4wz8C

4wz8C

PDB Chain 4wz8C

Image of CATH 4wz8B01

4wz8B01

CATH Domain 4wz8B01

Image of CATH 4wz8B02

4wz8B02

CATH Domain 4wz8B02

Image of CATH 4wz8B03

4wz8B03

CATH Domain 4wz8B03

Image of CATH 4wz8C01

4wz8C01

CATH Domain 4wz8C01

Image of CATH 4wz8C02

4wz8C02

CATH Domain 4wz8C02

Image of CATH 4wz8C03

4wz8C03

CATH Domain 4wz8C03

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
B	22 Dec, 2014	Chopped
C	22 Dec, 2014	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4wz8B01	28 Dec, 2014	3.90.226.10	Assigned
4wz8B02	28 Dec, 2014	2.40.460.10	Assigned
4wz8B03	28 Dec, 2014	3.90.226.10	Assigned
4wz8C01	28 Dec, 2014	3.90.226.10	Assigned
4wz8C02	28 Dec, 2014	2.40.460.10	Assigned
4wz8C03	28 Dec, 2014	3.90.226.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q00955	ACAC_YEAST	Saccharomyces cerevisiae S288C	Acetyl-CoA carboxylase
Q00955	ACAC_YEAST	Saccharomyces cerevisiae S288C	Acetyl-CoA carboxylase