PDB 4wki

PDB Information

PDB4WKI
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Durham, T.B., Klimkowski, V.J., Rito, C.J., Marimuthu, J., Toth, J.L., Liu, C., Durbin, J.D., Stout, S.L., Adams, L., Swearingen, C., Lin, C., Chambers, M.G., Thirunavukkarasu, K., Wiley, M.R.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-10-02
Resolution1.600
CATH Insert Date21 Dec, 2014

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 22 Dec, 2014 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4wkiA00 28 Dec, 2014 3.40.390.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
O75173 ATS4_HUMAN Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 4