PDB 4w9k

PDB Information

PDB4W9K
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderTranscription
Released2014-08-27
Resolution2.100
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9kA00 17 Sep, 2014 3.10.20.90 Assigned
4w9kB00 16 Sep, 2014 3.30.710.10 Assigned
4w9kC01 16 Sep, 2014 2.60.40.780 Assigned
4w9kC02 16 Sep, 2014 1.10.750.10 Assigned
4w9kD00 16 Sep, 2014 3.10.20.90 Assigned
4w9kE00 17 Sep, 2014 3.30.710.10 Assigned
4w9kF01 17 Sep, 2014 2.60.40.780 Assigned
4w9kF02 17 Sep, 2014 1.10.750.10 Assigned
4w9kG00 17 Sep, 2014 3.10.20.90 Assigned
4w9kH00 17 Sep, 2014 3.30.710.10 Assigned
4w9kI01 16 Sep, 2014 2.60.40.780 Assigned
4w9kI02 16 Sep, 2014 1.10.750.10 Assigned
4w9kJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9kK00 17 Sep, 2014 3.30.710.10 Assigned
4w9kL01 16 Sep, 2014 2.60.40.780 Assigned
4w9kL02 16 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B