PDB 4w9d
PDB Information
| PDB | 4W9D |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli BL21(DE3) |
| Gene Source | Homo sapiens |
| Primary Citation | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|
| Header | Ligase |
| Released | 2014-08-27 |
| Resolution | 2.200 |
| CATH Insert Date | 14 Sep, 2014 |
PDB Images (29)
4w9d
PDB 4w9d
4w9dA
PDB Chain 4w9dA
4w9dB
PDB Chain 4w9dB
4w9dC
PDB Chain 4w9dC
4w9dD
PDB Chain 4w9dD
4w9dE
PDB Chain 4w9dE
4w9dF
PDB Chain 4w9dF
4w9dG
PDB Chain 4w9dG
4w9dH
PDB Chain 4w9dH
4w9dI
PDB Chain 4w9dI
4w9dJ
PDB Chain 4w9dJ
4w9dK
PDB Chain 4w9dK
4w9dL
PDB Chain 4w9dL
4w9dA00
CATH Domain 4w9dA00
4w9dB00
CATH Domain 4w9dB00
4w9dC01
CATH Domain 4w9dC01
4w9dC02
CATH Domain 4w9dC02
4w9dD00
CATH Domain 4w9dD00
4w9dE00
CATH Domain 4w9dE00
4w9dF01
CATH Domain 4w9dF01
4w9dF02
CATH Domain 4w9dF02
4w9dG00
CATH Domain 4w9dG00
4w9dH00
CATH Domain 4w9dH00
4w9dI01
CATH Domain 4w9dI01
4w9dI02
CATH Domain 4w9dI02
4w9dJ00
CATH Domain 4w9dJ00
4w9dK00
CATH Domain 4w9dK00
4w9dL01
CATH Domain 4w9dL01
4w9dL02
CATH Domain 4w9dL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 15 Sep, 2014 | Chopped |
| B | 15 Sep, 2014 | Chopped |
| C | 15 Sep, 2014 | Chopped |
| D | 15 Sep, 2014 | Chopped |
| E | 15 Sep, 2014 | Chopped |
| F | 15 Sep, 2014 | Chopped |
| G | 15 Sep, 2014 | Chopped |
| H | 15 Sep, 2014 | Chopped |
| I | 15 Sep, 2014 | Chopped |
| J | 15 Sep, 2014 | Chopped |
| K | 15 Sep, 2014 | Chopped |
| L | 15 Sep, 2014 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4w9dA00 | 17 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9dB00 | 17 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9dC01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9dC02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9dD00 | 17 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9dE00 | 17 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9dF01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9dF02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9dG00 | 17 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9dH00 | 17 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9dI01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9dI02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9dJ00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9dK00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9dL01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9dL02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
