PDB 4uw1

PDB Links
Overview

PDB Information

PDB	4UW1
Method	X-RAY DIFFRACTION
Host Organism	ESCHERICHIA COLI
Gene Source	HOMO SAPIENS
Primary Citation	Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors Elliot, R.J., Jarvis, A., Rajasekaran, M.B., Menon, M., Bowers, L., Boffey, R., Bayford, M., Firth-Clark, S., Beevers, R., Aquil, R., Kirton, S.B., Niculescu-Duvaz, D., Fish, L., Lopes, F., Mcleary, R., Trindade, I., Vendrell, E., Munkonge, F., Porter, R., Perrior, T., Springer, C., Oliver, A.W., Pearl, L.H., Ashworth, A., Lord, C.J. Medchemcommm
Header	Transferase
Released	2014-08-08
Resolution	3.370
CATH Insert Date	16 Aug, 2015

PDB Images (17)

4uw1

PDB 4uw1

4uw1A

PDB Chain 4uw1A

4uw1B

PDB Chain 4uw1B

4uw1C

PDB Chain 4uw1C

4uw1D

PDB Chain 4uw1D

4uw1E

PDB Chain 4uw1E

4uw1F

PDB Chain 4uw1F

4uw1G

PDB Chain 4uw1G

4uw1H

PDB Chain 4uw1H

4uw1A00

CATH Domain 4uw1A00

4uw1B00

CATH Domain 4uw1B00

4uw1C00

CATH Domain 4uw1C00

4uw1D00

CATH Domain 4uw1D00

4uw1E00

CATH Domain 4uw1E00

4uw1F00

CATH Domain 4uw1F00

4uw1G00

CATH Domain 4uw1G00

4uw1H00

CATH Domain 4uw1H00

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	17 Aug, 2015	Chopped
B	17 Aug, 2015	Chopped
C	17 Aug, 2015	Chopped
D	17 Aug, 2015	Chopped
E	17 Aug, 2015	Chopped
F	17 Aug, 2015	Chopped
G	17 Aug, 2015	Chopped
H	17 Aug, 2015	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4uw1A00	24 Aug, 2015	3.90.228.10	Assigned
4uw1B00	24 Aug, 2015	3.90.228.10	Assigned
4uw1C00	24 Aug, 2015	3.90.228.10	Assigned
4uw1D00	24 Aug, 2015	3.90.228.10	Assigned
4uw1E00	24 Aug, 2015	3.90.228.10	Assigned
4uw1F00	24 Aug, 2015	3.90.228.10	Assigned
4uw1G00	24 Aug, 2015	3.90.228.10	Assigned
4uw1H00	24 Aug, 2015	3.90.228.10	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1

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