PDB 4trz

PDB Information

PDB4TRZ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Hattori, Y., Kobayashi, K., Deguchi, A., Nohara, Y., Akiyama, T., Teruya, K., Sanjoh, A., Nakagawa, A., Yamashita, E., Akaji, K.
Bioorg.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-06-18
Resolution3.250
CATH Insert Date26 Jul, 2015

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 27 Jul, 2015 Chopped
B 27 Jul, 2015 Chopped
C 27 Jul, 2015 Chopped
D 27 Jul, 2015 Rejected
E 27 Jul, 2015 Rejected
F 27 Jul, 2015 Rejected

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4trzA01 30 Jul, 2015 2.40.70.10 Assigned
4trzA02 30 Jul, 2015 2.40.70.10 Assigned
4trzB01 30 Jul, 2015 2.40.70.10 Assigned
4trzB02 30 Jul, 2015 2.40.70.10 Assigned
4trzC01 30 Jul, 2015 2.40.70.10 Assigned
4trzC02 30 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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