PDB 4rcd

PDB Information

PDB4RCD
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Inhibitors of beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
Dineen, T.A., Chen, K., Cheng, A.C., Derakhchan, K., Epstein, O., Esmay, J., Hickman, D., Kreiman, C.E., Marx, I.E., Wahl, R.C., Wen, P.H., Weiss, M.M., Whittington, D.A., Wood, S., Fremeau, R.T., White, R.D., Patel, V.F.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-09-15
Resolution1.900
CATH Insert Date28 Jun, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4rcdA01 10 Jul, 2015 2.40.70.10 Assigned
4rcdA02 10 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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