PDB 4r8y

PDB Links
Overview

PDB Information

PDB	4R8Y
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of potent iminoheterocycle BACE1 inhibitors. Caldwell, J.P., Mazzola, R.D., Durkin, J., Chen, J., Chen, X., Favreau, L., Kennedy, M., Kuvelkar, R., Lee, J., McHugh, N., McKittrick, B., Orth, P., Stamford, A., Strickland, C., Voigt, J., Wang, L., Zhang, L., Zhang, Q., Zhu, Z. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-03
Resolution	1.900
CATH Insert Date	16 Nov, 2014

PDB Images (7)

Image of CATH 4r8y

4r8y

PDB 4r8y

Image of CATH 4r8yA

4r8yA

PDB Chain 4r8yA

Image of CATH 4r8yB

4r8yB

PDB Chain 4r8yB

Image of CATH 4r8yA01

4r8yA01

CATH Domain 4r8yA01

Image of CATH 4r8yA02

4r8yA02

CATH Domain 4r8yA02

Image of CATH 4r8yB01

4r8yB01

CATH Domain 4r8yB01

Image of CATH 4r8yB02

4r8yB02

CATH Domain 4r8yB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	17 Nov, 2014	Chopped
B	17 Nov, 2014	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4r8yA01	19 Nov, 2014	2.40.70.10	Assigned
4r8yA02	19 Nov, 2014	2.40.70.10	Assigned
4r8yB01	19 Nov, 2014	2.40.70.10	Assigned
4r8yB02	19 Nov, 2014	2.40.70.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1