PDB Information

PDB4QLT
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes
De Bruin, G., Huber, E.M., Xin, B.T., Van Rooden, E.J., Al-Ayed, K., Kim, K.B., Kisselev, A.F., Driessen, C., Van der Stelt, M., Van der Marel, G.A., Groll, M., Overkleeft, H.S.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-06-13
Resolution2.800
CATH Insert Date10 Aug, 2014

PDB Images (57)

PDB Prints

PDB Chains (28)

Chain ID Date inserted into CATH CATH Status
a 11 Aug, 2014 Chopped
A 11 Aug, 2014 Chopped
b 11 Aug, 2014 Chopped
B 11 Aug, 2014 Chopped
C 11 Aug, 2014 Chopped
D 11 Aug, 2014 Chopped
E 11 Aug, 2014 Chopped
F 11 Aug, 2014 Chopped
G 11 Aug, 2014 Chopped
H 11 Aug, 2014 Chopped
I 11 Aug, 2014 Chopped
J 11 Aug, 2014 Chopped
K 11 Aug, 2014 Chopped
L 11 Aug, 2014 Chopped
M 11 Aug, 2014 Chopped
N 11 Aug, 2014 Chopped
O 11 Aug, 2014 Chopped
P 11 Aug, 2014 Chopped
Q 11 Aug, 2014 Chopped
R 11 Aug, 2014 Chopped
S 11 Aug, 2014 Chopped
T 11 Aug, 2014 Chopped
U 11 Aug, 2014 Chopped
V 11 Aug, 2014 Chopped
W 11 Aug, 2014 Chopped
X 11 Aug, 2014 Chopped
Y 11 Aug, 2014 Chopped
Z 11 Aug, 2014 Chopped

CATH Domains (28)

Domain ID Date inserted into CATH Superfamily CATH Status
4qlta00 20 Aug, 2014 3.60.20.10 Assigned
4qltA00 20 Aug, 2014 3.60.20.10 Assigned
4qltb00 20 Aug, 2014 3.60.20.10 Assigned
4qltB00 20 Aug, 2014 3.60.20.10 Assigned
4qltC00 20 Aug, 2014 3.60.20.10 Assigned
4qltD00 20 Aug, 2014 3.60.20.10 Assigned
4qltE00 20 Aug, 2014 3.60.20.10 Assigned
4qltF00 20 Aug, 2014 3.60.20.10 Assigned
4qltG00 20 Aug, 2014 3.60.20.10 Assigned
4qltH00 20 Aug, 2014 3.60.20.10 Assigned
4qltI00 20 Aug, 2014 3.60.20.10 Assigned
4qltJ00 20 Aug, 2014 3.60.20.10 Assigned
4qltK00 20 Aug, 2014 3.60.20.10 Assigned
4qltL00 20 Aug, 2014 3.60.20.10 Assigned
4qltM00 20 Aug, 2014 3.60.20.10 Assigned
4qltN00 20 Aug, 2014 3.60.20.10 Assigned
4qltO00 20 Aug, 2014 3.60.20.10 Assigned
4qltP00 20 Aug, 2014 3.60.20.10 Assigned
4qltQ00 20 Aug, 2014 3.60.20.10 Assigned
4qltR00 20 Aug, 2014 3.60.20.10 Assigned
4qltS00 20 Aug, 2014 3.60.20.10 Assigned
4qltT00 20 Aug, 2014 3.60.20.10 Assigned
4qltU00 20 Aug, 2014 3.60.20.10 Assigned
4qltV00 20 Aug, 2014 3.60.20.10 Assigned
4qltW00 20 Aug, 2014 3.60.20.10 Assigned
4qltX00 20 Aug, 2014 3.60.20.10 Assigned
4qltY00 20 Aug, 2014 3.60.20.10 Assigned
4qltZ00 20 Aug, 2014 3.60.20.10 Assigned

UniProtKB Entries (28)

Accession Gene ID Taxon Description
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P38624 PSB1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-1
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P40302 PSA6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-6
P21243 PSA1_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-1
P22141 PSB4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-4
P30656 PSB5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-5
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5
P23639 PSA2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-2
P23638 PSA3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-3
P23724 PSB6_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-6
P21242 PSA7_YEAST Saccharomyces cerevisiae S288C Probable proteasome subunit alpha type-7
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P25451 PSB3_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-3
P30657 PSB7_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-7
P40303 PSA4_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-4
P25043 PSB2_YEAST Saccharomyces cerevisiae S288C Proteasome subunit beta type-2
P32379 PSA5_YEAST Saccharomyces cerevisiae S288C Proteasome subunit alpha type-5