PDB 4q6r

PDB Links
Overview

PDB Information

PDB	4Q6R
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Weiler, S., Braendlin, N., Beerli, C., Bergsdorf, C., Schubart, A., Srinivas, H., Oberhauser, B., Billich, A. J.Med.Chem.
Header	Lyase/Lyase Inhibitor
Released	2014-04-23
Resolution	2.400
CATH Insert Date	25 May, 2014

PDB Images (9)

Image of CATH 4q6r

4q6r

PDB 4q6r

Image of CATH 4q6rA

4q6rA

PDB Chain 4q6rA

Image of CATH 4q6rB

4q6rB

PDB Chain 4q6rB

Image of CATH 4q6rA01

4q6rA01

CATH Domain 4q6rA01

Image of CATH 4q6rA02

4q6rA02

CATH Domain 4q6rA02

Image of CATH 4q6rA03

4q6rA03

CATH Domain 4q6rA03

Image of CATH 4q6rB01

4q6rB01

CATH Domain 4q6rB01

Image of CATH 4q6rB02

4q6rB02

CATH Domain 4q6rB02

Image of CATH 4q6rB03

4q6rB03

CATH Domain 4q6rB03

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	26 May, 2014	Chopped
B	26 May, 2014	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4q6rA01	28 May, 2014	6.10.140.2150	Assigned
4q6rA02	28 May, 2014	3.90.1150.10	Assigned
4q6rA03	28 May, 2014	3.40.640.10	Assigned
4q6rB01	28 May, 2014	6.10.140.2150	Assigned
4q6rB02	28 May, 2014	3.90.1150.10	Assigned
4q6rB03	28 May, 2014	3.40.640.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O95470	SGPL1_HUMAN	Homo sapiens	Sphingosine-1-phosphate lyase 1
O95470	SGPL1_HUMAN	Homo sapiens	Sphingosine-1-phosphate lyase 1