PDB 4q50

PDB Information

PDB4Q50
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Fanning, S.W., Mayne, C.G., Dharmarajan, V., Carlson, K.E., Martin, T.A., Novick, S.J., Toy, W., Green, B., Panchamukhi, S., Katzenellenbogen, B.S., Tajkhorshid, E., Griffin, P.R., Shen, Y., Chandarlapaty, S., Katzenellenbogen, J.A., Greene, G.L.
Elife
HeaderHormone Binding Protein
Released2014-04-15
Resolution3.070
CATH Insert Date28 Jun, 2015

PDB Images (17)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped
E 29 Jun, 2015 Chopped
F 29 Jun, 2015 Chopped
G 29 Jun, 2015 Chopped
H 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4q50A00 10 Jul, 2015 1.10.565.10 Assigned
4q50B00 10 Jul, 2015 1.10.565.10 Assigned
4q50C00 10 Jul, 2015 1.10.565.10 Assigned
4q50D00 10 Jul, 2015 1.10.565.10 Assigned
4q50E00 10 Jul, 2015 1.10.565.10 Assigned
4q50F00 10 Jul, 2015 1.10.565.10 Assigned
4q50G00 10 Jul, 2015 1.10.565.10 Assigned
4q50H00 10 Jul, 2015 1.10.565.10 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor