PDB 4phw

PDB Links
Overview

PDB Information

PDB	4PHW
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A). Hu, E., Chen, N., Bourbeau, M.P., Harrington, P.E., Biswas, K., Kunz, R.K., Andrews, K.L., Chmait, S., Zhao, X., Davis, C., Ma, J., Shi, J., Lester-Zeiner, D., Danao, J., Able, J., Cueva, M., Talreja, S., Kornecook, T., Chen, H., Porter, A., Hungate, R., Treanor, J., Allen, J.R. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-05-07
Resolution	2.500
CATH Insert Date	24 Aug, 2014

PDB Images (5)

Image of CATH 4phw

4phw

PDB 4phw

Image of CATH 4phwA

4phwA

PDB Chain 4phwA

Image of CATH 4phwB

4phwB

PDB Chain 4phwB

Image of CATH 4phwA00

4phwA00

CATH Domain 4phwA00

Image of CATH 4phwB00

4phwB00

CATH Domain 4phwB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	25 Aug, 2014	Chopped
B	25 Aug, 2014	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4phwA00	27 Aug, 2014	1.10.1300.10	Assigned
4phwB00	27 Aug, 2014	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A