PDB Information

PDB4PH4
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle, W.E., Nyfeler, B., Nagel, J., Elling, R.A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., Cantwell, J., Luu, C., Cornella-Taracido, I., Harrington, E., Fekkes, P., Lei, H., Fang, Q., Digan, M.E., Burdick, D., Powers, A.F., Helliwell, S.B., D'Aquin, S., Bastien, J., Wang, H., Wiederschain, D., Kuerth, J., Bergman, P., Schwalb, D., Thomas, J., Ugwonali, S., Harbinski, F., Tallarico, J., Wilson, C.J., Myer, V.E., Porter, J.A., Bussiere, D.E., Finan, P.M., Labow, M.A., Mao, X., Hamann, L.G., Manning, B.D., Valdez, R.A., Nicholson, T., Schirle, M., Knapp, M.S., Keaney, E.P., Murphy, L.O.
Nat.Cell Biol.
HeaderTransferase/Transferase Inhibitor
Released2014-05-04
Resolution2.800
CATH Insert Date09 Nov, 2014

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
B 10 Nov, 2014 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4ph4B01 13 Nov, 2014 1.25.40.70 Assigned
4ph4B02 13 Nov, 2014 3.30.1010.10 Assigned
4ph4B03 13 Nov, 2014 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q8NEB9 PK3C3_HUMAN Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3