PDB 4pfc

PDB Information

PDB4PFC
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Durham, T.B., Toth, J.L., Klimkowski, V.J., Cao, J.X., Siesky, A.M., Alexander-Chacko, J., Wu, G.Y., Dixon, J.T., McGee, J.E., Wang, Y., Guo, S.Y., Cavitt, R.N., Schindler, J., Thibodeaux, S.J., Calvert, N.A., Coghlan, M.J., Sindelar, D.K., Christe, M., Kiselyov, V.V., Michael, M.D., Sloop, K.W.
J.Biol.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2014-04-28
Resolution2.210
CATH Insert Date28 Jun, 2015

PDB Images (11)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4pfcA01 10 Jul, 2015 3.30.830.10 Assigned
4pfcA02 10 Jul, 2015 3.30.830.10 Assigned
4pfcA03 10 Jul, 2015 3.30.830.10 Assigned
4pfcA04 10 Jul, 2015 3.30.830.10 Assigned
4pfcB01 10 Jul, 2015 3.30.830.10 Assigned
4pfcB02 10 Jul, 2015 3.30.830.10 Assigned
4pfcB03 10 Jul, 2015 3.30.830.10 Assigned
4pfcB04 10 Jul, 2015 3.30.830.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme
P14735 IDE_HUMAN Homo sapiens Insulin-degrading enzyme