PDB 4p38

PDB Information

PDB4P38
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
Scott, J.S., deSchoolmeester, J., Kilgour, E., Mayers, R.M., Packer, M.J., Hargreaves, D., Gerhardt, S., Ogg, D.J., Rees, A., Selmi, N., Stocker, A., Swales, J.G., Whittamore, P.R.
J.Med.Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2014-03-06
Resolution2.800
CATH Insert Date04 May, 2014

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 May, 2014 Chopped
B 05 May, 2014 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4p38A00 08 May, 2014 3.40.50.720 Assigned
4p38B00 09 May, 2014 3.40.50.720 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1