PDB 4ncg

PDB Information

PDB4NCG
MethodX-RAY DIFFRACTION
Host Organism
Gene SourceHuman immunodeficiency virus 1
Primary Citation
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Cote, B., Burch, J.D., Asante-Appiah, E., Bayly, C., Bedard, L., Blouin, M., Campeau, L.C., Cauchon, E., Chan, M., Chefson, A., Coulombe, N., Cromlish, W., Debnath, S., Deschenes, D., Dupont-Gaudet, K., Falgueyret, J.P., Forget, R., Gagne, S., Gauvreau, D., Girardin, M., Guiral, S., Langlois, E., Li, C.S., Nguyen, N., Papp, R., Plamondon, S., Roy, A., Roy, S., Seliniotakis, R., St-Onge, M., Ouellet, S., Tawa, P., Truchon, J.F., Vacca, J., Wrona, M., Yan, Y., Ducharme, Y.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Inhhibitor, Hydrolase/Inhhib
Released2013-10-24
Resolution2.580
CATH Insert Date16 Feb, 2014

PDB Images (12)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 17 Feb, 2014 Chopped
B 17 Feb, 2014 Chopped

CATH Domains (9)

Domain ID Date inserted into CATH Superfamily CATH Status
4ncgA01 07 Mar, 2014 3.10.10.10 Assigned
4ncgA02 07 Mar, 2014 3.30.70.270 Assigned
4ncgA03 07 Mar, 2014 3.30.70.270 Assigned
4ncgA04 07 Mar, 2014 3.30.70.270 Assigned
4ncgA05 07 Mar, 2014 3.30.420.10 Assigned
4ncgB01 07 Mar, 2014 3.10.10.10 Assigned
4ncgB02 07 Mar, 2014 3.30.70.270 Assigned
4ncgB03 07 Mar, 2014 3.30.70.270 Assigned
4ncgB04 07 Mar, 2014 3.30.70.270 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein