×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

PDB 4m49

PDB Information

PDB4M49
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Fauber, B.P., Dragovich, P.S., Chen, J., Corson, L.B., Ding, C.Z., Eigenbrot, C., Giannetti, A.M., Hunsaker, T., Labadie, S., Liu, Y., Liu, Y., Malek, S., Peterson, D., Pitts, K., Sideris, S., Ultsch, M., Vanderporten, E., Wang, J., Wei, B., Yen, I., Yue, Q.
Bioorg.Med.Chem.Lett.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2013-08-06
Resolution2.050
CATH Insert Date22 Sep, 2013

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 23 Sep, 2013 Chopped
B 23 Sep, 2013 Chopped
C 23 Sep, 2013 Chopped
D 23 Sep, 2013 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4m49A01 25 Sep, 2013 3.40.50.720 Assigned
4m49A02 25 Sep, 2013 3.90.110.10 Assigned
4m49B01 25 Sep, 2013 3.40.50.720 Assigned
4m49B02 25 Sep, 2013 3.90.110.10 Assigned
4m49C01 25 Sep, 2013 3.40.50.720 Assigned
4m49C02 25 Sep, 2013 3.90.110.10 Assigned
4m49D01 25 Sep, 2013 3.40.50.720 Assigned
4m49D02 25 Sep, 2013 3.90.110.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
CATH-Gene3D is a Global Biodata Core Resource Learn more...