PDB 4lxk

PDB Links
Overview

PDB Information

PDB	4LXK
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Rueeger, H., Lueoend, R., Machauer, R., Veenstra, S.J., Jacobson, L.H., Staufenbiel, M., Desrayaud, S., Rondeau, J.M., Mobitz, H., Neumann, U. Bioorg.Med.Chem.Lett.
Header	Hydrolase/Hydrolase Inhibitor
Released	2013-07-30
Resolution	2.050
CATH Insert Date	15 Sep, 2013

PDB Images (10)

Image of CATH 4lxk

4lxk

PDB 4lxk

Image of CATH 4lxkA

4lxkA

PDB Chain 4lxkA

Image of CATH 4lxkB

4lxkB

PDB Chain 4lxkB

Image of CATH 4lxkC

4lxkC

PDB Chain 4lxkC

Image of CATH 4lxkA01

4lxkA01

CATH Domain 4lxkA01

Image of CATH 4lxkA02

4lxkA02

CATH Domain 4lxkA02

Image of CATH 4lxkB01

4lxkB01

CATH Domain 4lxkB01

Image of CATH 4lxkB02

4lxkB02

CATH Domain 4lxkB02

Image of CATH 4lxkC01

4lxkC01

CATH Domain 4lxkC01

Image of CATH 4lxkC02

4lxkC02

CATH Domain 4lxkC02

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	16 Sep, 2013	Chopped
B	16 Sep, 2013	Chopped
C	16 Sep, 2013	Chopped

CATH Domains (6)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lxkA01	01 Nov, 2013	2.40.70.10	Assigned
4lxkA02	01 Nov, 2013	2.40.70.10	Assigned
4lxkB01	01 Nov, 2013	2.40.70.10	Assigned
4lxkB02	01 Nov, 2013	2.40.70.10	Assigned
4lxkC01	01 Nov, 2013	2.40.70.10	Assigned
4lxkC02	01 Nov, 2013	2.40.70.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1