PDB 4lwv

PDB Links
Overview

PDB Information

PDB	4LWV
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Xenopus laevis
Primary Citation	Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. Zhang, Z., Chu, X.J., Liu, J.J., Ding, Q., Zhang, J., Bartkovitz, D., Jiang, N., Karnachi, P., So, S.S., Tovar, C., Filipovic, Z.M., Higgins, B., Glenn, K., Packman, K., Vassilev, L., Graves, B. ACS MED.CHEM.LETT.
Header	Ligase/Ligase Inhibitor
Released	2013-07-28
Resolution	2.320
CATH Insert Date	20 Jul, 2014

PDB Images (7)

Image of CATH 4lwv

4lwv

PDB 4lwv

Image of CATH 4lwvA

4lwvA

PDB Chain 4lwvA

Image of CATH 4lwvB

4lwvB

PDB Chain 4lwvB

Image of CATH 4lwvC

4lwvC

PDB Chain 4lwvC

Image of CATH 4lwvA00

4lwvA00

CATH Domain 4lwvA00

Image of CATH 4lwvB00

4lwvB00

CATH Domain 4lwvB00

Image of CATH 4lwvC00

4lwvC00

CATH Domain 4lwvC00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	21 Jul, 2014	Chopped
B	21 Jul, 2014	Chopped
C	21 Jul, 2014	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lwvA00	03 Aug, 2014	1.10.245.10	Assigned
4lwvB00	27 Jul, 2014	1.10.245.10	Assigned
4lwvC00	03 Aug, 2014	1.10.245.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P56273	MDM2_XENLA	Xenopus laevis	E3 ubiquitin-protein ligase Mdm2
P56273	MDM2_XENLA	Xenopus laevis	E3 ubiquitin-protein ligase Mdm2
P56273	MDM2_XENLA	Xenopus laevis	E3 ubiquitin-protein ligase Mdm2