PDB 4lwt

PDB Links
Overview

PDB Information

PDB	4LWT
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Xenopus laevis
Primary Citation	Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Zhang, Z., Ding, Q., Liu, J.J., Zhang, J., Jiang, N., Chu, X.J., Bartkovitz, D., Luk, K.C., Janson, C., Tovar, C., Filipovic, Z.M., Higgins, B., Glenn, K., Packman, K., Vassilev, L.T., Graves, B. Bioorg.Med.Chem.
Header	Ligase/Ligase Inhibitor
Released	2013-07-28
Resolution	1.600
CATH Insert Date	27 Jul, 2014

PDB Images (3)

Image of CATH 4lwt

4lwt

PDB 4lwt

Image of CATH 4lwtA

4lwtA

PDB Chain 4lwtA

Image of CATH 4lwtA00

4lwtA00

CATH Domain 4lwtA00

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	28 Jul, 2014	Chopped

CATH Domains (1)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4lwtA00	03 Aug, 2014	1.10.245.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
P56273	MDM2_XENLA	Xenopus laevis	E3 ubiquitin-protein ligase Mdm2