PDB 4loy

PDB Information

PDB4LOY
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Schreuder, H., Alet, N., Herault, J.P., Millet, L., Dol, F., Florian, P., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.M.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2013-07-14
Resolution1.770
CATH Insert Date15 Jun, 2014

PDB Images (6)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
H 16 Jun, 2014 Chopped
I 16 Jun, 2014 Rejected
L 16 Jun, 2014 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4loyH01 18 Jun, 2014 2.40.10.10 Assigned
4loyH02 18 Jun, 2014 2.40.10.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P09945 HIRV2_HIRME Hirudo medicinalis Hirudin variant-2
P00734 THRB_HUMAN Homo sapiens Prothrombin
P00734 THRB_HUMAN Homo sapiens Prothrombin