PDB 4li6

PDB Information

PDB4LI6
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of NVP-TNKS656: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor.
Shultz, M.D., Cheung, A.K., Kirby, C.A., Firestone, B., Fan, J., Chen, C.H., Chen, Z., Chin, D.N., Dipietro, L., Fazal, A., Feng, Y., Fortin, P.D., Gould, T., Lagu, B., Lei, H., Lenoir, F., Majumdar, D., Ochala, E., Palermo, M.G., Pham, L., Pu, M., Smith, T., Stams, T., Tomlinson, R.C., Toure, B.B., Visser, M., Wang, R.M., Waters, N.J., Shao, W.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-07-02
Resolution2.050
CATH Insert Date01 Sep, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2013 Chopped
B 02 Sep, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4li6A00 04 Sep, 2013 3.90.228.10 Assigned
4li6B00 04 Sep, 2013 3.90.228.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1