PDB Information

PDB4KSQ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives.
Okaniwa, M., Hirose, M., Arita, T., Yabuki, M., Nakamura, A., Takagi, T., Kawamoto, T., Uchiyama, N., Sumita, A., Tsutsumi, S., Tottori, T., Inui, Y., Sang, B.C., Yano, J., Aertgeerts, K., Yoshida, S., Ishikawa, T.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-05-17
Resolution3.300
CATH Insert Date04 Aug, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Aug, 2013 Chopped
B 05 Aug, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4ksqA01 14 Aug, 2013 3.30.200.20 Assigned
4ksqA02 14 Aug, 2013 1.10.510.10 Assigned
4ksqB01 14 Aug, 2013 3.30.200.20 Assigned
4ksqB02 14 Aug, 2013 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf
P15056 BRAF_HUMAN Homo sapiens Serine/threonine-protein kinase B-raf