PDB 4jty

PDB Information

PDB4JTY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency.
Hucke, O., Coulombe, R., Bonneau, P., Bertrand-Laperle, M., Brochu, C., Gillard, J., Joly, M.A., Landry, S., Lepage, O., Llinas-Brunet, M., Pesant, M., Poirier, M., Poirier, M., McKercher, G., Marquis, M., Kukolj, G., Beaulieu, P.L., Stammers, T.A.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-03-24
Resolution2.600
CATH Insert Date04 Aug, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Aug, 2013 Chopped
B 05 Aug, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4jtyA01 08 Oct, 2013 Holding pen
4jtyA02 08 Oct, 2013 Holding pen
4jtyB01 08 Oct, 2013 Holding pen
4jtyB02 08 Oct, 2013 Holding pen

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O92972 POLG_HCVJ4 Hepatitis C virus isolate HC-J4 Genome polyprotein
O92972 POLG_HCVJ4 Hepatitis C virus isolate HC-J4 Genome polyprotein