Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid beta in a higher species.
Hunt, K.W., Cook, A.W., Watts, R.J., Clark, C.T., Vigers, G., Smith, D., Metcalf, A.T., Gunawardana, I.W., Burkard, M., Cox, A.A., Geck Do, M.K., Dutcher, D., Thomas, A.A., Rana, S., Kallan, N.C., DeLisle, R.K., Rizzi, J.P., Regal, K., Sammond, D., Groneberg, R., Siu, M., Purkey, H., Lyssikatos, J.P., Marlow, A., Liu, X., Tang, T.P.
J.Med.Chem.