PDB Information

PDB4IVB
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
Zak, M., Hurley, C.A., Ward, S.I., Bergeron, P., Barrett, K., Balazs, M., Blair, W.S., Bull, R., Chakravarty, P., Chang, C., Crackett, P., Deshmukh, G., Devoss, J., Dragovich, P.S., Eigenbrot, C., Ellwood, C., Gaines, S., Ghilardi, N., Gibbons, P., Gradl, S., Gribling, P., Hamman, C., Harstad, E., Hewitt, P., Johnson, A., Johnson, T., Kenny, J.R., Koehler, M.F., Bir Kohli, P., Labadie, S., Lee, W.P., Liao, J., Liimatta, M., Mendonca, R., Narukulla, R., Pulk, R., Reeve, A., Savage, S., Shia, S., Steffek, M., Ubhayakar, S., van Abbema, A., Aliagas, I., Avitabile-Woo, B., Xiao, Y., Yang, J., Kulagowski, J.J.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-01-22
Resolution1.900
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4ivbA01 09 Aug, 2013 3.30.200.20 Assigned
4ivbA02 09 Aug, 2013 1.10.510.10 Assigned
4ivbB01 09 Aug, 2013 3.30.200.20 Assigned
4ivbB02 09 Aug, 2013 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1