PDB 4in4

PDB Information

PDB4IN4
MethodX-RAY DIFFRACTION
Host OrganismEscherichia Coli
Gene SourceHomo sapiens
Primary Citation
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Marcotte, D., Zeng, W., Hus, J.C., McKenzie, A., Hession, C., Jin, P., Bergeron, C., Lugovskoy, A., Enyedy, I., Cuervo, H., Wang, D., Atmanene, C., Roecklin, D., Vecchi, M., Vivat, V., Kraemer, J., Winkler, D., Hong, V., Chao, J., Lukashev, M., Silvian, L.
Bioorg.Med.Chem.
HeaderTranscription
Released2013-01-03
Resolution2.590
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped
C 08 Jul, 2013 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
4in4A00 09 Aug, 2013 2.120.10.80 Assigned
4in4B00 09 Aug, 2013 2.120.10.80 Assigned
4in4C00 09 Aug, 2013 2.120.10.80 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q14145 KEAP1_HUMAN Homo sapiens Kelch-like ECH-associated protein 1
Q14145 KEAP1_HUMAN Homo sapiens Kelch-like ECH-associated protein 1
Q14145 KEAP1_HUMAN Homo sapiens Kelch-like ECH-associated protein 1