PDB 4i8x

PDB Links
Overview

PDB Information

PDB	4I8X
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. Kohlmann, A., Zech, S.G., Li, F., Zhou, T., Squillace, R.M., Commodore, L., Greenfield, M.T., Lu, X., Miller, D.P., Huang, W.S., Qi, J., Thomas, R.M., Wang, Y., Zhang, S., Dodd, R., Liu, S., Xu, R., Xu, Y., Miret, J.J., Rivera, V., Clackson, T., Shakespeare, W.C., Zhu, X., Dalgarno, D.C. J.Med.Chem.
Header	Oxidoreductase/Oxidoreductase Inhibitor
Released	2012-12-04
Resolution	2.230
CATH Insert Date	27 Jan, 2013

PDB Images (25)

4i8x

PDB 4i8x

4i8xA

PDB Chain 4i8xA

4i8xB

PDB Chain 4i8xB

4i8xC

PDB Chain 4i8xC

4i8xD

PDB Chain 4i8xD

4i8xE

PDB Chain 4i8xE

4i8xF

PDB Chain 4i8xF

4i8xG

PDB Chain 4i8xG

4i8xH

PDB Chain 4i8xH

4i8xA01

CATH Domain 4i8xA01

4i8xA02

CATH Domain 4i8xA02

4i8xB01

CATH Domain 4i8xB01

4i8xB02

CATH Domain 4i8xB02

4i8xC01

CATH Domain 4i8xC01

4i8xC02

CATH Domain 4i8xC02

4i8xD01

CATH Domain 4i8xD01

4i8xD02

CATH Domain 4i8xD02

4i8xE01

CATH Domain 4i8xE01

4i8xE02

CATH Domain 4i8xE02

4i8xF01

CATH Domain 4i8xF01

4i8xF02

CATH Domain 4i8xF02

4i8xG01

CATH Domain 4i8xG01

4i8xG02

CATH Domain 4i8xG02

4i8xH01

CATH Domain 4i8xH01

4i8xH02

CATH Domain 4i8xH02

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	28 Jan, 2013	Chopped
B	28 Jan, 2013	Chopped
C	28 Jan, 2013	Chopped
D	28 Jan, 2013	Chopped
E	28 Jan, 2013	Chopped
F	28 Jan, 2013	Chopped
G	28 Jan, 2013	Chopped
H	28 Jan, 2013	Chopped

CATH Domains (16)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4i8xA01	02 Feb, 2013	3.40.50.720	Assigned
4i8xA02	02 Feb, 2013	3.90.110.10	Assigned
4i8xB01	01 Feb, 2013	3.40.50.720	Assigned
4i8xB02	01 Feb, 2013	3.90.110.10	Assigned
4i8xC01	02 Feb, 2013	3.40.50.720	Assigned
4i8xC02	02 Feb, 2013	3.90.110.10	Assigned
4i8xD01	02 Feb, 2013	3.40.50.720	Assigned
4i8xD02	02 Feb, 2013	3.90.110.10	Assigned
4i8xE01	02 Feb, 2013	3.40.50.720	Assigned
4i8xE02	02 Feb, 2013	3.90.110.10	Assigned
4i8xF01	02 Feb, 2013	3.40.50.720	Assigned
4i8xF02	02 Feb, 2013	3.90.110.10	Assigned
4i8xG01	02 Feb, 2013	3.40.50.720	Assigned
4i8xG02	02 Feb, 2013	3.90.110.10	Assigned
4i8xH01	02 Feb, 2013	3.40.50.720	Assigned
4i8xH02	02 Feb, 2013	3.90.110.10	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain
P13491	LDHA_RABIT	Oryctolagus cuniculus	L-lactate dehydrogenase A chain