PDB 4hz5

PDB Links
Overview

PDB Information

PDB	4HZ5
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Enterococcus faecalis
Primary Citation	Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J. Bioorg.Med.Chem.Lett.
Header	Isomerase/Isomerase Inhibitor
Released	2012-11-14
Resolution	2.700
CATH Insert Date	28 Mar, 2013

PDB Images (19)

4hz5

PDB 4hz5

4hz5A

PDB Chain 4hz5A

4hz5B

PDB Chain 4hz5B

4hz5C

PDB Chain 4hz5C

4hz5D

PDB Chain 4hz5D

4hz5E

PDB Chain 4hz5E

4hz5F

PDB Chain 4hz5F

4hz5G

PDB Chain 4hz5G

4hz5H

PDB Chain 4hz5H

4hz5J

PDB Chain 4hz5J

4hz5A00

CATH Domain 4hz5A00

4hz5B00

CATH Domain 4hz5B00

4hz5C00

CATH Domain 4hz5C00

4hz5D00

CATH Domain 4hz5D00

4hz5E00

CATH Domain 4hz5E00

4hz5F00

CATH Domain 4hz5F00

4hz5G00

CATH Domain 4hz5G00

4hz5H00

CATH Domain 4hz5H00

4hz5J00

CATH Domain 4hz5J00

PDB Prints

PDB Chains (9)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2013	Chopped
B	28 Mar, 2013	Chopped
C	28 Mar, 2013	Chopped
D	28 Mar, 2013	Chopped
E	28 Mar, 2013	Chopped
F	28 Mar, 2013	Chopped
G	28 Mar, 2013	Chopped
H	28 Mar, 2013	Chopped
J	28 Mar, 2013	Chopped

CATH Domains (9)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hz5A00	01 Jul, 2013	3.30.565.10	Assigned
4hz5B00	01 Jul, 2013	3.30.565.10	Assigned
4hz5C00	01 Jul, 2013	3.30.565.10	Assigned
4hz5D00	01 Jul, 2013	3.30.565.10	Assigned
4hz5E00	01 Jul, 2013	3.30.565.10	Assigned
4hz5F00	01 Jul, 2013	3.30.565.10	Assigned
4hz5G00	01 Jul, 2013	3.30.565.10	Assigned
4hz5H00	01 Jul, 2013	3.30.565.10	Assigned
4hz5J00	01 Jul, 2013	3.30.565.10	Assigned

UniProtKB Entries (9)

Accession	Gene ID	Taxon	Description
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B
H7C794	PARE_ENTFA	Enterococcus faecalis V583	DNA topoisomerase 4 subunit B