PDB 4hz0

PDB Information

PDB4HZ0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceEscherichia coli
Primary Citation
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J.
Bioorg.Med.Chem.Lett.
HeaderIsomerase/Isomerase Inhibitor
Released2012-11-14
Resolution2.200
CATH Insert Date28 Mar, 2013

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped
B 28 Mar, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4hz0A00 01 Jul, 2013 3.30.565.10 Assigned
4hz0B00 01 Jul, 2013 3.30.565.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P20083 PARE_ECOLI Escherichia coli K-12 DNA topoisomerase 4 subunit B
P20083 PARE_ECOLI Escherichia coli K-12 DNA topoisomerase 4 subunit B
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