PDB 4hyp

PDB Links
Overview

PDB Information

PDB	4HYP
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Escherichia coli
Primary Citation	Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J. Bioorg.Med.Chem.Lett.
Header	Isomerase/Isomerase Inhibitor
Released	2012-11-13
Resolution	2.600
CATH Insert Date	28 Mar, 2013

PDB Images (9)

Image of CATH 4hyp

4hyp

PDB 4hyp

Image of CATH 4hypA

4hypA

PDB Chain 4hypA

Image of CATH 4hypB

4hypB

PDB Chain 4hypB

Image of CATH 4hypC

4hypC

PDB Chain 4hypC

Image of CATH 4hypD

4hypD

PDB Chain 4hypD

Image of CATH 4hypA00

4hypA00

CATH Domain 4hypA00

Image of CATH 4hypB00

4hypB00

CATH Domain 4hypB00

Image of CATH 4hypC00

4hypC00

CATH Domain 4hypC00

Image of CATH 4hypD00

4hypD00

CATH Domain 4hypD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2013	Chopped
B	28 Mar, 2013	Chopped
C	28 Mar, 2013	Chopped
D	28 Mar, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hypA00	01 Jul, 2013	3.30.565.10	Assigned
4hypB00	01 Jul, 2013	3.30.565.10	Assigned
4hypC00	01 Jul, 2013	3.30.565.10	Assigned
4hypD00	01 Jul, 2013	3.30.565.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P0AES6	GYRB_ECOLI	Escherichia coli K-12	DNA gyrase subunit B
P0AES6	GYRB_ECOLI	Escherichia coli K-12	DNA gyrase subunit B
P0AES6	GYRB_ECOLI	Escherichia coli K-12	DNA gyrase subunit B
P0AES6	GYRB_ECOLI	Escherichia coli K-12	DNA gyrase subunit B