PDB 4hxz

PDB Links
Overview

PDB Information

PDB	4HXZ
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Francisella tularensis subsp. holarctica
Primary Citation	Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J. Bioorg.Med.Chem.Lett.
Header	Isomerase/Isomerase Inhibitor
Released	2012-11-12
Resolution	2.700
CATH Insert Date	28 Mar, 2013

PDB Images (7)

Image of CATH 4hxz

4hxz

PDB 4hxz

Image of CATH 4hxzA

4hxzA

PDB Chain 4hxzA

Image of CATH 4hxzB

4hxzB

PDB Chain 4hxzB

Image of CATH 4hxzA01

4hxzA01

CATH Domain 4hxzA01

Image of CATH 4hxzA02

4hxzA02

CATH Domain 4hxzA02

Image of CATH 4hxzB01

4hxzB01

CATH Domain 4hxzB01

Image of CATH 4hxzB02

4hxzB02

CATH Domain 4hxzB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	28 Mar, 2013	Chopped
B	28 Mar, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hxzA01	17 Apr, 2013	3.30.565.10	Assigned
4hxzA02	17 Apr, 2013	3.30.230.10	Assigned
4hxzB01	01 Aug, 2013	3.30.565.10	Assigned
4hxzB02	01 Aug, 2013		Cathedral cath submit

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
A0A0J9WZF0	PARE_FRATH	Francisella tularensis subsp. holarctica LVS	DNA topoisomerase 4 subunit B
A0A0J9WZF0	PARE_FRATH	Francisella tularensis subsp. holarctica LVS	DNA topoisomerase 4 subunit B