PDB 4hw3
PDB Information
| PDB | 4HW3 |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Homo sapiens |
| Primary Citation | Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem.
|
| Header | Apoptosis/Inhibitor |
| Released | 2012-11-07 |
| Resolution | 2.400 |
| CATH Insert Date | 20 Jan, 2013 |
PDB Images (25)
4hw3
PDB 4hw3
4hw3A
PDB Chain 4hw3A
4hw3B
PDB Chain 4hw3B
4hw3C
PDB Chain 4hw3C
4hw3D
PDB Chain 4hw3D
4hw3E
PDB Chain 4hw3E
4hw3F
PDB Chain 4hw3F
4hw3G
PDB Chain 4hw3G
4hw3H
PDB Chain 4hw3H
4hw3I
PDB Chain 4hw3I
4hw3J
PDB Chain 4hw3J
4hw3K
PDB Chain 4hw3K
4hw3L
PDB Chain 4hw3L
4hw3A01
CATH Domain 4hw3A01
4hw3B01
CATH Domain 4hw3B01
4hw3C01
CATH Domain 4hw3C01
4hw3D01
CATH Domain 4hw3D01
4hw3E01
CATH Domain 4hw3E01
4hw3F01
CATH Domain 4hw3F01
4hw3G01
CATH Domain 4hw3G01
4hw3H01
CATH Domain 4hw3H01
4hw3I01
CATH Domain 4hw3I01
4hw3J01
CATH Domain 4hw3J01
4hw3K01
CATH Domain 4hw3K01
4hw3L01
CATH Domain 4hw3L01
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 21 Jan, 2013 | Chopped |
| B | 21 Jan, 2013 | Chopped |
| C | 21 Jan, 2013 | Chopped |
| D | 21 Jan, 2013 | Chopped |
| E | 21 Jan, 2013 | Chopped |
| F | 21 Jan, 2013 | Chopped |
| G | 21 Jan, 2013 | Chopped |
| H | 21 Jan, 2013 | Chopped |
| I | 21 Jan, 2013 | Chopped |
| J | 21 Jan, 2013 | Chopped |
| K | 21 Jan, 2013 | Chopped |
| L | 21 Jan, 2013 | Chopped |
CATH Domains (12)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4hw3A01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3B01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3C01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3D01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3E01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3F01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3G01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3H01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3I01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3J01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3K01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
| 4hw3L01 | 24 Jan, 2013 | 1.10.437.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Q07820 | MCL1_HUMAN | Homo sapiens | Induced myeloid leukemia cell differentiation protein Mcl-1 |