PDB 4hw2

PDB Information

PDB4HW2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg, A., Vigil, D., Zhao, B., Daniels, R.N., Burke, J.P., Garcia-Barrantes, P.M., Camper, D., Chauder, B.A., Lee, T., Olejniczak, E.T., Fesik, S.W.
J.Med.Chem.
HeaderApoptosis/Inhibitor
Released2012-11-07
Resolution2.800
CATH Insert Date20 Jan, 2013

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 21 Jan, 2013 Chopped
B 21 Jan, 2013 Chopped
C 21 Jan, 2013 Chopped
D 21 Jan, 2013 Chopped
E 21 Jan, 2013 Chopped
F 21 Jan, 2013 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
4hw2A01 24 Jan, 2013 1.10.437.10 Assigned
4hw2B01 24 Jan, 2013 1.10.437.10 Assigned
4hw2C01 24 Jan, 2013 1.10.437.10 Assigned
4hw2D01 24 Jan, 2013 1.10.437.10 Assigned
4hw2E01 24 Jan, 2013 1.10.437.10 Assigned
4hw2F01 24 Jan, 2013 1.10.437.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820 MCL1_HUMAN Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1
CATH-Gene3D is a Global Biodata Core Resource Learn more...