PDB 4hrd

PDB Links
Overview

PDB Information

PDB	4HRD
Method	X-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation	Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Trivella, D.B., Pereira, A.R., Stein, M.L., Kasai, Y., Byrum, T., Valeriote, F.A., Tantillo, D.J., Groll, M., Gerwick, W.H., Moore, B.S. Chem.Biol.
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-10-27
Resolution	2.800
CATH Insert Date	02 Feb, 2014

PDB Images (57)

4hrd

PDB 4hrd

4hrda

PDB Chain 4hrda

4hrdA

PDB Chain 4hrdA

4hrdb

PDB Chain 4hrdb

4hrdB

PDB Chain 4hrdB

4hrdC

PDB Chain 4hrdC

4hrdD

PDB Chain 4hrdD

4hrdE

PDB Chain 4hrdE

4hrdF

PDB Chain 4hrdF

4hrdG

PDB Chain 4hrdG

4hrdH

PDB Chain 4hrdH

4hrdI

PDB Chain 4hrdI

4hrdJ

PDB Chain 4hrdJ

4hrdK

PDB Chain 4hrdK

4hrdL

PDB Chain 4hrdL

4hrdM

PDB Chain 4hrdM

4hrdN

PDB Chain 4hrdN

4hrdO

PDB Chain 4hrdO

4hrdP

PDB Chain 4hrdP

4hrdQ

PDB Chain 4hrdQ

4hrdR

PDB Chain 4hrdR

4hrdS

PDB Chain 4hrdS

4hrdT

PDB Chain 4hrdT

4hrdU

PDB Chain 4hrdU

4hrdV

PDB Chain 4hrdV

4hrdW

PDB Chain 4hrdW

4hrdX

PDB Chain 4hrdX

4hrdY

PDB Chain 4hrdY

4hrdZ

PDB Chain 4hrdZ

4hrda00

CATH Domain 4hrda00

4hrdA00

CATH Domain 4hrdA00

4hrdb00

CATH Domain 4hrdb00

4hrdB00

CATH Domain 4hrdB00

4hrdC00

CATH Domain 4hrdC00

4hrdD00

CATH Domain 4hrdD00

4hrdE00

CATH Domain 4hrdE00

4hrdF00

CATH Domain 4hrdF00

4hrdG00

CATH Domain 4hrdG00

4hrdH00

CATH Domain 4hrdH00

4hrdI00

CATH Domain 4hrdI00

4hrdJ00

CATH Domain 4hrdJ00

4hrdK00

CATH Domain 4hrdK00

4hrdL00

CATH Domain 4hrdL00

4hrdM00

CATH Domain 4hrdM00

4hrdN00

CATH Domain 4hrdN00

4hrdO00

CATH Domain 4hrdO00

4hrdP00

CATH Domain 4hrdP00

4hrdQ00

CATH Domain 4hrdQ00

4hrdR00

CATH Domain 4hrdR00

4hrdS00

CATH Domain 4hrdS00

4hrdT00

CATH Domain 4hrdT00

4hrdU00

CATH Domain 4hrdU00

4hrdV00

CATH Domain 4hrdV00

4hrdW00

CATH Domain 4hrdW00

4hrdX00

CATH Domain 4hrdX00

4hrdY00

CATH Domain 4hrdY00

4hrdZ00

CATH Domain 4hrdZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2014	Chopped
A	03 Feb, 2014	Chopped
b	03 Feb, 2014	Chopped
B	03 Feb, 2014	Chopped
C	03 Feb, 2014	Chopped
D	03 Feb, 2014	Chopped
E	03 Feb, 2014	Chopped
F	03 Feb, 2014	Chopped
G	03 Feb, 2014	Chopped
H	03 Feb, 2014	Chopped
I	03 Feb, 2014	Chopped
J	03 Feb, 2014	Chopped
K	03 Feb, 2014	Chopped
L	03 Feb, 2014	Chopped
M	03 Feb, 2014	Chopped
N	03 Feb, 2014	Chopped
O	03 Feb, 2014	Chopped
P	03 Feb, 2014	Chopped
Q	03 Feb, 2014	Chopped
R	03 Feb, 2014	Chopped
S	03 Feb, 2014	Chopped
T	03 Feb, 2014	Chopped
U	03 Feb, 2014	Chopped
V	03 Feb, 2014	Chopped
W	03 Feb, 2014	Chopped
X	03 Feb, 2014	Chopped
Y	03 Feb, 2014	Chopped
Z	03 Feb, 2014	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4hrda00	07 Mar, 2014	3.60.20.10	Assigned
4hrdA00	07 Mar, 2014	3.60.20.10	Assigned
4hrdb00	07 Mar, 2014	3.60.20.10	Assigned
4hrdB00	07 Mar, 2014	3.60.20.10	Assigned
4hrdC00	07 Mar, 2014	3.60.20.10	Assigned
4hrdD00	07 Mar, 2014	3.60.20.10	Assigned
4hrdE00	07 Mar, 2014	3.60.20.10	Assigned
4hrdF00	07 Mar, 2014	3.60.20.10	Assigned
4hrdG00	07 Mar, 2014	3.60.20.10	Assigned
4hrdH00	07 Mar, 2014	3.60.20.10	Assigned
4hrdI00	07 Mar, 2014	3.60.20.10	Assigned
4hrdJ00	07 Mar, 2014	3.60.20.10	Assigned
4hrdK00	07 Mar, 2014	3.60.20.10	Assigned
4hrdL00	07 Mar, 2014	3.60.20.10	Assigned
4hrdM00	07 Mar, 2014	3.60.20.10	Assigned
4hrdN00	07 Mar, 2014	3.60.20.10	Assigned
4hrdO00	07 Mar, 2014	3.60.20.10	Assigned
4hrdP00	07 Mar, 2014	3.60.20.10	Assigned
4hrdQ00	07 Mar, 2014	3.60.20.10	Assigned
4hrdR00	07 Mar, 2014	3.60.20.10	Assigned
4hrdS00	07 Mar, 2014	3.60.20.10	Assigned
4hrdT00	07 Mar, 2014	3.60.20.10	Assigned
4hrdU00	07 Mar, 2014	3.60.20.10	Assigned
4hrdV00	07 Mar, 2014	3.60.20.10	Assigned
4hrdW00	07 Mar, 2014	3.60.20.10	Assigned
4hrdX00	07 Mar, 2014	3.60.20.10	Assigned
4hrdY00	07 Mar, 2014	3.60.20.10	Assigned
4hrdZ00	07 Mar, 2014	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P25043	PSB2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1