PDB 4hra

PDB Information

PDB4HRA
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Daigle, S.R., Olhava, E.J., Therkelsen, C.A., Basavapathruni, A., Jin, L., Boriack-Sjodin, P.A., Allain, C.J., Klaus, C.R., Raimondi, A., Scott, M.P., Waters, N.J., Chesworth, R., Moyer, M.P., Copeland, R.A., Richon, V.M., Pollock, R.M.
Blood
HeaderTransferase/Transferase Inhibitor
Released2012-10-26
Resolution3.150
CATH Insert Date18 Aug, 2013

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 19 Aug, 2013 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4hraA01 23 Aug, 2013 1.10.260.60 Assigned
4hraA02 23 Aug, 2013 3.40.50.150 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q8TEK3 DOT1L_HUMAN Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific