PDB Information

PDB4HEU
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux.
Rzasa, R.M., Hu, E., Rumfelt, S., Chen, N., Andrews, K.L., Chmait, S., Falsey, J.R., Zhong, W., Jones, A.D., Porter, A., Louie, S.W., Zhao, X., Treanor, J.J., Allen, J.R.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-10-04
Resolution2.000
CATH Insert Date30 Dec, 2012

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 31 Dec, 2012 Chopped
B 31 Dec, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4heuA00 08 Feb, 2013 1.10.1300.10 Assigned
4heuB00 08 Feb, 2013 1.10.1300.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233 PDE10_HUMAN Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A