PDB 4gj8

PDB Information

PDB4GJ8
MethodX-RAY DIFFRACTION
Host OrganismCricetulus griseus
Gene SourceHomo sapiens
Primary Citation
A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann, N., Ruedisser, S., Ehrhardt, C., Breitenstein, W., Marzinzik, A., Jacoby, E., Vangrevelinghe, E., Ottl, J., Klumpp, M., Hartwieg, J.C., Cumin, F., Hassiepen, U., Trappe, J., Sedrani, R., Geisse, S., Gerhartz, B., Richert, P., Francotte, E., Wagner, T., Kromer, M., Kosaka, T., Webb, R.L., Rigel, D.F., Maibaum, J., Baeschlin, D.K.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-08-09
Resolution2.500
CATH Insert Date28 Mar, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped
B 28 Mar, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4gj8A01 04 Nov, 2013 2.40.70.10 Assigned
4gj8A02 04 Nov, 2013 2.40.70.10 Assigned
4gj8B01 04 Nov, 2013 2.40.70.10 Assigned
4gj8B02 04 Nov, 2013 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin