PDB 4gj5

PDB Information

PDB4GJ5
MethodX-RAY DIFFRACTION
Host OrganismCricetulus griseus
Gene SourceHomo sapiens
Primary Citation
The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches.
Lorthiois, E., Breitenstein, W., Cumin, F., Ehrhardt, C., Francotte, E., Jacoby, E., Ostermann, N., Sellner, H., Kosaka, T., Webb, R.L., Rigel, D.F., Hassiepen, U., Richert, P., Wagner, T., Maibaum, J.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2012-08-09
Resolution2.400
CATH Insert Date28 Mar, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Mar, 2013 Chopped
B 28 Mar, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4gj5A01 04 Nov, 2013 2.40.70.10 Assigned
4gj5A02 04 Nov, 2013 2.40.70.10 Assigned
4gj5B01 04 Nov, 2013 2.40.70.10 Assigned
4gj5B02 04 Nov, 2013 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin