PDB 4fsl

PDB Information

PDB4FSL
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Acyl Guanidine Inhibitors of beta-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Gerritz, S.W., Zhai, W., Shi, S., Zhu, S., Toyn, J.H., Meredith, J.E., Iben, L.G., Burton, C.R., Albright, C.F., Good, A.C., Tebben, A.J., Muckelbauer, J.K., Camac, D.M., Metzler, W., Cook, L.S., Padmanabha, R., Lentz, K.A., Sofia, M.J., Poss, M.A., Macor, J.E., Thompson, L.A.
J.Med.Chem.
HeaderHydrolase/Inhibitor
Released2012-06-27
Resolution2.500
CATH Insert Date04 Nov, 2012

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped
D 05 Nov, 2012 Chopped
E 05 Nov, 2012 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4fslA01 10 Nov, 2012 2.40.70.10 Assigned
4fslA02 10 Nov, 2012 2.40.70.10 Assigned
4fslB01 10 Nov, 2012 2.40.70.10 Assigned
4fslB02 10 Nov, 2012 2.40.70.10 Assigned
4fslD01 10 Nov, 2012 2.40.70.10 Assigned
4fslD02 10 Nov, 2012 2.40.70.10 Assigned
4fslE01 10 Nov, 2012 2.40.70.10 Assigned
4fslE02 10 Nov, 2012 2.40.70.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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