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PDB 4fse

PDB Information

PDB4FSE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Acyl guanidine inhibitors of beta-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis
Gerritz, S.W., Zhai, W., Shi, S., Zhu, S., Toyn, J.H., Meredith, J.E., Iben, L.G., Burton, C.R., Albright, C.F., Good, A.C., Tebben, A.J., Muckelbauer, J.K., Camac, D.M., Metzler, W., Cook, L.S., Padmanabha, R., Lentz, K.A., Sofia, M.J., Poss, M.A., Macor, J.E., Thompson, L.A.
J.Med.Chem.
HeaderHydrolase/Inhibitor
Released2012-06-27
Resolution2.650
CATH Insert Date04 Nov, 2012

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped
B 05 Nov, 2012 Chopped
D 05 Nov, 2012 Chopped
E 05 Nov, 2012 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4fseA01 10 Nov, 2012 2.40.70.10 Assigned
4fseA02 10 Nov, 2012 2.40.70.10 Assigned
4fseB01 10 Nov, 2012 2.40.70.10 Assigned
4fseB02 10 Nov, 2012 2.40.70.10 Assigned
4fseD01 10 Nov, 2012 2.40.70.10 Assigned
4fseD02 10 Nov, 2012 2.40.70.10 Assigned
4fseE01 10 Nov, 2012 2.40.70.10 Assigned
4fseE02 10 Nov, 2012 2.40.70.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
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