PDB 4frs

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PDB Links
Overview

PDB Information

PDB	4FRS
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS A(beta) Reduction Stamford, A.W., Scott, J.D., Li, S.W., Babu, S., Tadesse, D., Hunter, R., Wu, Y., Misiaszek, J., Cumming, J.N., Gilbert, E.J., Huang, C., McKittrick, B.A., Hong, L., Guo, T., Zhu, Z., Strickland, C., Orth, P., Voigt, J.H., Kennedy, M.E., Chen, X., Kuvelkar, R., Hodgson, R., Hyde, L.A., Cox, K., Favreau, L., Parker, E.M., Greenlee, W.J. ACS Med Chem Lett
Header	Hydrolase/Hydrolase Inhibitor
Released	2012-06-26
Resolution	1.700
CATH Insert Date	04 Nov, 2012

PDB Images (7)

Image of CATH 4frs

4frs

PDB 4frs

Image of CATH 4frsA

4frsA

PDB Chain 4frsA

Image of CATH 4frsB

4frsB

PDB Chain 4frsB

Image of CATH 4frsA01

4frsA01

CATH Domain 4frsA01

Image of CATH 4frsA02

4frsA02

CATH Domain 4frsA02

Image of CATH 4frsB01

4frsB01

CATH Domain 4frsB01

Image of CATH 4frsB02

4frsB02

CATH Domain 4frsB02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	05 Nov, 2012	Chopped
B	05 Nov, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4frsA01	10 Nov, 2012	2.40.70.10	Assigned
4frsA02	10 Nov, 2012	2.40.70.10	Assigned
4frsB01	10 Nov, 2012	2.40.70.10	Assigned
4frsB02	10 Nov, 2012	2.40.70.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1
P56817	BACE1_HUMAN	Homo sapiens	Beta-secretase 1