PDB 4fk6

PDB Links
Overview

PDB Information

PDB	4FK6
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2. Labadie, S., Dragovich, P.S., Barrett, K., Blair, W.S., Bergeron, P., Chang, C., Deshmukh, G., Eigenbrot, C., Ghilardi, N., Gibbons, P., Hurley, C.A., Johnson, A., Kenny, J.R., Kohli, P.B., Kulagowski, J.J., Liimatta, M., Lupardus, P.J., Mendonca, R., Murray, J.M., Pulk, R., Shia, S., Steffek, M., Ubhayakar, S., Ultsch, M., van Abbema, A., Ward, S., Zak, M. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2012-06-12
Resolution	2.200
CATH Insert Date	11 Nov, 2012

PDB Images (7)

Image of CATH 4fk6

4fk6

PDB 4fk6

Image of CATH 4fk6A

4fk6A

PDB Chain 4fk6A

Image of CATH 4fk6B

4fk6B

PDB Chain 4fk6B

Image of CATH 4fk6A01

4fk6A01

CATH Domain 4fk6A01

Image of CATH 4fk6A02

4fk6A02

CATH Domain 4fk6A02

Image of CATH 4fk6B01

4fk6B01

CATH Domain 4fk6B01

Image of CATH 4fk6B02

4fk6B02

CATH Domain 4fk6B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	12 Nov, 2012	Chopped
B	12 Nov, 2012	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4fk6A01	19 Nov, 2012	3.30.200.20	Assigned
4fk6A02	19 Nov, 2012	1.10.510.10	Assigned
4fk6B01	19 Nov, 2012	3.30.200.20	Assigned
4fk6B02	19 Nov, 2012	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1
P23458	JAK1_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK1