PDB Information

PDB4FA6
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kalpha and mTOR
Le, P.T., Cheng, H., Ninkovic, S., Plewe, M., Huang, X., Wang, H., Bagrodia, S., Sun, S., Knighton, D.R., LaFleur Rogers, C.M., Pannifer, A., Greasley, S., Dalvie, D., Zhang, E.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2012-05-21
Resolution2.700
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
4fa6A01 10 Oct, 2013 3.10.20.90 Assigned
4fa6A02 10 Oct, 2013 2.60.40.150 Assigned
4fa6A03 10 Oct, 2013 1.25.40.70 Assigned
4fa6A04 10 Oct, 2013 3.30.1010.10 Assigned
4fa6A05 10 Oct, 2013 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform