PDB 4eki

PDB Information

PDB4EKI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L.
Basavapathruni, A., Jin, L., Daigle, S.R., Majer, C.R., Therkelsen, C.A., Wigle, T.J., Kuntz, K.W., Chesworth, R., Pollock, R.M., Scott, M.P., Moyer, M.P., Richon, V.M., Copeland, R.A., Olhava, E.J.
Chem.Biol.Drug Des.
HeaderTransferase/Transferase Inhibitor
Released2012-04-09
Resolution2.850
CATH Insert Date04 Nov, 2012

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Nov, 2012 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4ekiA01 18 Apr, 2013 1.10.260.60 Assigned
4ekiA02 18 Apr, 2013 3.40.50.150 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q8TEK3 DOT1L_HUMAN Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific